Live scores for all game appear below the preview.
Barcelona visit Eibar in the early Saturday kick-off. Later on, Real Madrid face RCD Mallorca.
Atlético Madrid, meanwhile, face a tricky test against Valencia at the Wanda Metropolitano on Saturday afternoon.
Granada host Osasuna in the only Friday game. In the remaining Saturday fixture apart from the aforementioned ones, Getafe host Leganés.
La Liga fans are in for a treat on Sunday with five matches on the cards. Alavés host Celta Vigo before Real Betis visit Real Sociedad.
Espanyol are in action against Villarreal with Athletic Bilbao set to play host to Valladolid.
Sevilla will be looking to bounce back from a 4-0 loss to Barcelona before the international window when they return to action at home to Levante.
La Liga: Fixtures, results and live scores 18-20 October
Scores will be live at kick off.