It’s a match up many Manchester United fans have been dreaming of ever since the English Premier League trophies dried up at the end of Sir Alex Ferguson’s Old Trafford reign.
Bitter rivals Liverpool have risen back to prominence under Jurgen Klopp since, winning their first EPL crown in 30 long years last season.
And the duo meet at Anfield on Sunday first and second in the table, with the Reds stuttering and United flying, so strap in for a belter.
Across the north west, Pep Guardiola’s in-form Manchester City welcome Crystal Palace to the Etihad Stadium.
Tottenham, meanwhile, head to a Sheffield United side that finally collected their first victory of a torrid campaign in midweek.
Arsenal, who had their winning run curtailed by Palace on Thursday night, must wait until Monday to host Newcastle, who were vanquished by the Blades at Bramall Lane.
Saturday sees five Premier League fixtures, headed up by a west London derby between Fulham and Chelsea at Craven Cottage.
There’s another derby in the lunchtime kick off when Wolves and West Brom meet at Molineux for a Black Country clash.
Leicester and Southampton bookend the day’s action in the late fixture, as the battle for Europe heats up at the King Power Stadium.
It’s a riot of claret and blue at the London Stadium with West Ham hosting Burnley, while Leeds are at home to a Brighton side in increasing need of a win.
Aston Villa’s meeting with Everton, scheduled for Sunday, has been postponed thanks to a Covid-19 outbreak in the home camp.
English Premier League predictions for this week
Prediction methodology explained: The expected win percentage is based off publicly available odds. For example, if a team’s odds are 2.30, the expected chance of winning is 43%. If the odds are 1.62 the expected chance of winning is 62% and so on. These are accurate at the time of writing but are subject to change. Where there is no value listed, the odds were not available at the time of writing.