A blockbuster weekend of Fifa World Cup action kicks off on Friday with the start of the second round of pool fixtures in Qatar.
England and the United States of America bring things to a climax in the late Group B match after Wales scrap it out with Iran earlier in the day.
The Netherlands can seal qualification from Group A, as can opponents Ecuador, if either snaffles three points from their clash, with hosts Qatar and Senegal each seeking to get on the board.
World Cup predictions and fixtures for 25 November
*All kick off times are in Central Africa Time.
Group A: Qatar vs Senegal – 15.00
Desperation is in the air as host nation Qatar face off with Senegal in the second round of Group A fixtures at the 2022 Fifa World Cup.
Both lost their opening games to leave them needing points on the board sharpish to avoid elimination.
The absence of star man Sadio Mane hit the Lions of Teranga hard as they failed to stay the course with the Netherlands on Monday.
Ecuador breezed to victory, meanwhile, over what could well become only the second host nation to fail to qualify from the group stage of the tournament.
Group A: Netherlands vs Ecuador – 18.00
Knockout qualification is on the line for the Netherlands and Ecuador, who meet knowing another three points would take either through from Group A at the earliest available opportunity.
Both were 2-0 winners in the opening round of games.
The Dutch finished the stronger to see off African champions Senegal, with Cody Gakpo and Davy Klaassen doing the late damage.
Any opening night nerves were soon dealt with by the South Americans, too, as Enner Valencia notched twice inside the first half an hour of the competition in the Al Bayt Stadium.
Group B: Wales vs Iran – 12.00
Minnows Wales and Iran kick off the second round of pool fixtures on Friday afternoon, as Group B starts to take shape at the 2022 Fifa World Cup in Qatar.
Gareth Bale was the penalty spot hero as the Welsh pulled level against the USA inside the last ten minutes four days ago, sending 3 000 red-shirted fans into a frenzy behind the goal.
No such luck for the Iranians, whose entirely understandable off-field issues looked like overwhelming them at points of their heavy defeat against impressive England.
Mehdi Taremi did at least net twice, including a penalty as the amount of added time stretched credulity at the Khalifa International Stadium.
Group B: England vs USA – 21.00
England face the United States of America on Friday night, knowing a win will seal safe passage from World Cup Group B with a match to spare.
A 6-2 drubbing of Iran put Gareth Southgate’s men on the perfect track as they look to at least emulate their semi-final odyssey of four years ago.
Injury concern over captain and star striker Harry Kane is the only potential cloud, although the scoresheet somehow evaded the Tottenham forward on Monday in any case.
The States thought they were on for three points in their opening game with Wales as well, only to fail to match their first half intensity and precision in slipping to a 1-1 draw.